RNAi 🔬 Discovered 🔎

RNAi Discovered

NOVA science NOW 

Posted 07.26.05

RNA, the close chemical cousin of DNA, was once thought to be a bit player in the life of a cell, but not anymore. RNA is now at the heart of a scientific and medical revolution. 

It’s a revolution that started with the cultivation of a purple petunia,

and it has led scientists to what may be the most important advance in biology in decades. 

Through a process known as RNAi (the "i" is for interference), researchers have a new way to shut off specific genes, yielding insights into the human genome as well as providing potential treatments for a wide range of diseases.

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RNAi Discovered

Teachers' Domain: RNAi Discovered

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http://www.teachersdomain.org/resource/lsps07.sci.life.gen.rnai/

This video segment adapted from NOVA scienceNOW explores a mechanism called RNA interference (RNAi), which has evolved in cells to prevent viral infection. Cells must carefully regulate the synthesis of proteins from genes to ensure normal development and to prevent disease. Having accidentally discovered this mechanism while experimenting with color in petunias, scientists now know that RNAi serves a critical role in this process. 

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Related Resources

RNAi: Expert Q&A

On July 28, 2005, molecular biologist Greg Hannon answered questions about RNAi and its potential applications combating viruses, delaying aging, and treating various diseases.

Dr. Gregory Hannon is a researcher on the forefront of the field of RNA interference, a powerful new tool for gene analysis, discovery, and suppression. Full Bio

http://www.pbs.org/wgbh/nova/body/hannon-rnai.html

RNAi Therapy

In this video segment adapted from NOVA scienceNOW, learn how RNA interference (RNAi), a mechanism that operates in cells to silence gene expression, is being explored by researchers as a therapeutic approach to treating a host of diseases. 

A genetic malfunction is causing a patient to lose her vision because of the over-production of blood vessels in her eyes. To treat this genetic malfunctioning, scientists attempt to manipulate the mechanism so that genes that normally trigger production of blood vessels instead do the opposite.

http://www.pbs.org/wgbh/nova/education/body/rnai-therapy.html

 

RNAi  Explained

 

What is RNAi and how does it work? 

RNAi, short for "RNA interference," is a remarkable way to shut down the expression of genes. Harnessing its power could lead to great advances in medical science and molecular biology. 

But how does it work? 

In this interactive, see RNAi explained both through easy-to-grasp cartoon metaphors as well as using the standard terms of biology textbooks.

http://www.pbs.org/wgbh/nova/body/rnai-explained.html

The RNAi Cure?

Will RNAi, already in human clinical trials, treat a host of diseases, including AIDS, cancer, and Huntington's?

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It may work in the lab, but will RNAi radically change the practice of medicine?

http://www.pbs.org/wgbh/nova/body/rnai-cure.html

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RNA 🧪Antisense 👩‍🔬 (August 2003)

Messenger RNA (mRNA) is a single stranded molecule that is used as the template for protein translation. It is possible for RNA to form duplexes, similar to DNA, with a second sequence of RNA complementary to the first strand. This second sequence is called antisense RNA (Figure 1). The formation of double stranded RNA can inhibit gene expression in many different organisms including plants, flies, worms and fungi.

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https://paulcpw.blogspot.com/2012/11/rna-antisense.html
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RNAi 🔬 Discovered - NOVA science NOW 
Posted 07.26.05
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https://paulcpw.blogspot.com/2012/12/rnai-discovered.html
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🧪Inside the Lab That Invented 👨‍🔬
💉The COVID-19 🦠Vaccine💉
Dec 8, 2020
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https://paulcpw.blogspot.com/2020/12/lab-inventedcovid-19vaccine-rnai.html
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RNAi 🧪Discovered

RNA, the close chemical cousin of DNA, was once thought to be a bit player in the life of a cell, but not anymore. RNA is now at the heart of a scientific and medical revolution.
It’s a revolution that started with the cultivation of a purple petunia...

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https://paulcpw.blogspot.com/2019/01/rnai-discovered.html
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