RNAi Discovered
NOVA science NOW
Posted 07.26.05
RNA, the close chemical cousin of DNA, was once thought to be a bit
player in the life of a cell, but not anymore. RNA is now at the heart
of a scientific and medical revolution.
It’s a revolution that started
with the cultivation of a purple petunia,
and it has led scientists to
what may be the most important advance in biology in decades.
Through a
process known as RNAi (the "i" is for interference), researchers have a
new way to shut off specific genes, yielding insights into the human
genome as well as providing potential treatments for a wide range of
diseases.
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RNAi Discovered
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http://www.teachersdomain.org/resource/lsps07.sci.life.gen.rnai/
This video segment adapted from NOVA scienceNOW
explores a mechanism called RNA interference (RNAi), which has evolved
in cells to prevent viral infection. Cells must carefully regulate the
synthesis of proteins from genes to ensure normal development and to
prevent disease. Having accidentally discovered this mechanism while
experimenting with color in petunias, scientists now know that RNAi
serves a critical role in this process.
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RNAi: Expert Q&A
On July 28, 2005, molecular biologist Greg Hannon answered questions
about RNAi and its potential applications combating viruses, delaying
aging, and treating various diseases.
Dr. Gregory Hannon is a researcher on the forefront of the field of RNA interference, a powerful new tool for gene analysis, discovery, and suppression. Full Bio
In this video segment adapted from NOVA scienceNOW, learn how RNA interference (RNAi), a mechanism that operates in cells to silence gene expression, is being explored by researchers as a therapeutic approach to treating a host of diseases.
A genetic malfunction is causing a patient to lose her vision because of the over-production of blood vessels in her eyes. To treat this genetic malfunctioning, scientists attempt to manipulate the mechanism so that genes that normally trigger production of blood vessels instead do the opposite.
RNAi Explained
What is RNAi and how does it work?
RNAi, short for "RNA interference," is a remarkable way to shut down the expression of genes. Harnessing its power could lead to great advances in medical science and molecular biology.
But how does it work?
In this interactive, see RNAi explained both through easy-to-grasp cartoon metaphors as well as using the standard terms of biology textbooks.
The RNAi Cure?
Will RNAi, already in human clinical trials, treat a host of diseases, including AIDS, cancer, and Huntington's?
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It may work in the lab, but will RNAi radically change the practice of medicine?
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